5-Amino-1MQ
A selective NNMT inhibitor that preserves cellular NAD+ to enhance metabolic rate and reduce fat accumulation.
Also known as: NNMT Inhibitor, 5A1MQ
Available on Forge Amino
5-Amino-1MQ — independently lab tested, 99%+ purity, QR-linked COA.
Important: This content is for informational and research purposes only and is not intended for human or veterinary use. Consult your physician for health-related guidance and laboratory monitoring.
How It Works
Inhibits NNMT enzyme, blocking NAD+ conversion to 1-methylnicotinamide. Preserves intracellular NAD+ pools, enhancing mitochondrial function, oxidative capacity, and energy expenditure.
Key Benefits
- ✓35-40% reduction in fat mass (animal models)
- ✓Increased resting energy expenditure
- ✓Improved insulin sensitivity and glucose tolerance
- ✓50-60% reduction in fasting insulin
- ✓Enhanced mitochondrial function
Dosing Protocols
Beginner / Intermediate
Dose
50-100 mg
Frequency
Once daily oral with food
Cycle Length
4-8 weeks
Notes
Take earlier in day; avoid late afternoon dosing
Advanced
Dose
100-150 mg
Frequency
Twice daily oral
Cycle Length
8-12 weeks
Notes
Morning and afternoon dosing maximizes metabolic effect
Side Effects & Safety
Common Side Effects
- Temporary digestive changes
- Mild headaches
- Muscle soreness or fatigue
- Nausea or dizziness
- Sleep disturbance if taken late
Contraindications
- Pregnancy and breastfeeding
- Kidney or liver disease
- Active cancer treatment
- Eating disorders
- Uncontrolled cardiovascular disease
- Age <21
Stacking & Synergies
These compounds have complementary mechanisms and may enhance results when used together.
Key Takeaway
Burn more, store less: 5-Amino-1MQ unlocks your cells' metabolic potential by preserving NAD+.
Research Disclaimer: This content is for informational and research purposes only. It is not medical advice. These products are not approved by the FDA for human consumption. Consult a qualified healthcare provider before starting any new protocol. The information provided is based on preclinical research and anecdotal reports and has not been formally evaluated in randomized controlled trials.