NAD+ / NAD+ Precursors
Essential mitochondrial cofactor that declines with age. Supplementation enhances energy metabolism, DNA repair, and sirtuin activation.
Also known as: Nicotinamide Adenine Dinucleotide, NMN, NR
Important: This content is for informational and research purposes only and is not intended for human or veterinary use. Consult your physician for health-related guidance and laboratory monitoring.
How It Works
NAD+ serves as electron carrier in energy metabolism, substrate for sirtuins (longevity pathways), and PARPs (DNA repair). Precursors (NMN, NR) bypass GI degradation for superior bioavailability.
Key Benefits
- ✓Enhanced ATP production
- ✓Sirtuin activation (longevity pathways)
- ✓Improved mitochondrial function
- ✓Enhanced DNA repair capacity
- ✓Metabolic flexibility and energy
Dosing Protocols
Beginner / Intermediate
Dose
250 mg NMN
Frequency
Once daily oral
Cycle Length
4-8 weeks continuous
Notes
Or 500-750 mg IV NAD+ over 2-4 hours 1-2x/week
Advanced
Dose
500-1000 mg NMN
Frequency
Daily oral, or 100 mg NAD+ SubQ 2x/week
Cycle Length
8-12 weeks or ongoing
Notes
Combination approaches maximize NAD+ bioavailability
Side Effects & Safety
Common Side Effects
- IV: Nausea, flushing, headache (slow infusion mitigates)
- SubQ: Minor tingling or cramping
- Oral: Well-tolerated; rare nausea
- Most resolve within hours
Contraindications
- Cardiovascular disease (IV NAD+ especially)
- Hypotension (<100 mmHg systolic)
- Severe liver or kidney impairment
- Pregnancy and breastfeeding
- Concurrent MAOIs
Stacking & Synergies
These compounds have complementary mechanisms and may enhance results when used together.
Key Takeaway
Recharge your cells: NAD+ supplementation restores the fundamental currency of cellular energy.
Research Disclaimer: This content is for informational and research purposes only. It is not medical advice. These products are not approved by the FDA for human consumption. Consult a qualified healthcare provider before starting any new protocol. The information provided is based on preclinical research and anecdotal reports and has not been formally evaluated in randomized controlled trials.